Hypercalcemia in granulomatous disorders: a clinical review.
Identifieur interne : 002431 ( Main/Exploration ); précédent : 002430; suivant : 002432Hypercalcemia in granulomatous disorders: a clinical review.
Auteurs : O P Sharma [États-Unis]Source :
- Current opinion in pulmonary medicine [ 1070-5287 ] ; 2000.
Descripteurs français
- KwdFr :
- Calcitriol (métabolisme), Femelle, Granulome (), Granulome (diagnostic), Humains, Hypercalcémie (diagnostic), Hypercalcémie (métabolisme), Hypercalcémie (épidémiologie), Hypercalcémie (étiologie), Incidence, Mâle, Pneumopathies interstitielles (), Pneumopathies interstitielles (diagnostic), Pronostic, Évaluation des risques.
- MESH :
- diagnostic : Granulome, Hypercalcémie, Pneumopathies interstitielles.
- métabolisme : Calcitriol, Hypercalcémie.
- épidémiologie : Hypercalcémie.
- étiologie : Hypercalcémie.
- Femelle, Granulome, Humains, Incidence, Mâle, Pneumopathies interstitielles, Pronostic, Évaluation des risques.
English descriptors
- KwdEn :
- Calcitriol (metabolism), Female, Granuloma (complications), Granuloma (diagnosis), Humans, Hypercalcemia (diagnosis), Hypercalcemia (epidemiology), Hypercalcemia (etiology), Hypercalcemia (metabolism), Incidence, Lung Diseases, Interstitial (complications), Lung Diseases, Interstitial (diagnosis), Male, Prognosis, Risk Assessment.
- MESH :
- chemical , metabolism : Calcitriol.
- complications : Granuloma, Lung Diseases, Interstitial.
- diagnosis : Granuloma, Hypercalcemia, Lung Diseases, Interstitial.
- epidemiology : Hypercalcemia.
- etiology : Hypercalcemia.
- metabolism : Hypercalcemia.
- Female, Humans, Incidence, Male, Prognosis, Risk Assessment.
Abstract
Hypercalcemia occurs in most granulomatous disorders. High serum calcium levels are seen in about 10% of patients with sarcoidosis; hypercalciuria is about three times more frequent. Tuberculosis, fungal granulomas, berylliosis, and lymphomas are other conditions that are associated with disorders of calcium metabolism. These abnormalities of calcium metabolism are due to dysregulated production of 1,25-(OH2)D3 (calcitriol) by activated macrophages trapped in pulmonary alveoli and granulomatous inflammation. Undetected hypercalcemia and hypercalciuria can cause nephrocalcinosis, renal stones, and renal failure. Corticosteroids cause prompt reversal of the metabolic defect. Chloroquine, hydroxychloroquine, and ketoconazole are the drugs that should be used if the patient fails to respond or develops dangerous side effects to corticosteroid therapy.
DOI: 10.1097/00063198-200009000-00010
PubMed: 10958237
Affiliations:
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Le document en format XML
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Los Angeles, California 90033, USA. osharma@hsc.usc.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>LAC+USC Medical Center, Los Angeles, California 90033</wicri:regionArea><wicri:noRegion>California 90033</wicri:noRegion></affiliation></author></analytic><series><title level="j">Current opinion in pulmonary medicine</title><idno type="ISSN">1070-5287</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calcitriol (metabolism)</term><term>Female</term><term>Granuloma (complications)</term><term>Granuloma (diagnosis)</term><term>Humans</term><term>Hypercalcemia (diagnosis)</term><term>Hypercalcemia (epidemiology)</term><term>Hypercalcemia (etiology)</term><term>Hypercalcemia (metabolism)</term><term>Incidence</term><term>Lung Diseases, Interstitial (complications)</term><term>Lung Diseases, Interstitial (diagnosis)</term><term>Male</term><term>Prognosis</term><term>Risk Assessment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Calcitriol (métabolisme)</term><term>Femelle</term><term>Granulome ()</term><term>Granulome (diagnostic)</term><term>Humains</term><term>Hypercalcémie (diagnostic)</term><term>Hypercalcémie (métabolisme)</term><term>Hypercalcémie (épidémiologie)</term><term>Hypercalcémie (étiologie)</term><term>Incidence</term><term>Mâle</term><term>Pneumopathies interstitielles ()</term><term>Pneumopathies interstitielles (diagnostic)</term><term>Pronostic</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcitriol</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Granuloma</term><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Granuloma</term><term>Hypercalcemia</term><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Granulome</term><term>Hypercalcémie</term><term>Pneumopathies interstitielles</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hypercalcemia</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypercalcemia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hypercalcemia</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Calcitriol</term><term>Hypercalcémie</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Hypercalcémie</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hypercalcémie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Prognosis</term><term>Risk Assessment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Granulome</term><term>Humains</term><term>Incidence</term><term>Mâle</term><term>Pneumopathies interstitielles</term><term>Pronostic</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hypercalcemia occurs in most granulomatous disorders. High serum calcium levels are seen in about 10% of patients with sarcoidosis; hypercalciuria is about three times more frequent. Tuberculosis, fungal granulomas, berylliosis, and lymphomas are other conditions that are associated with disorders of calcium metabolism. These abnormalities of calcium metabolism are due to dysregulated production of 1,25-(OH2)D3 (calcitriol) by activated macrophages trapped in pulmonary alveoli and granulomatous inflammation. Undetected hypercalcemia and hypercalciuria can cause nephrocalcinosis, renal stones, and renal failure. Corticosteroids cause prompt reversal of the metabolic defect. Chloroquine, hydroxychloroquine, and ketoconazole are the drugs that should be used if the patient fails to respond or develops dangerous side effects to corticosteroid therapy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Sharma, O P" sort="Sharma, O P" uniqKey="Sharma O" first="O P" last="Sharma">O P Sharma</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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